An official publication of the Teratology Society
Special On-Line Issue:
Molecular Approaches to the Study of Birth Defects
-
Birth Defects Research (Part A): Clinical and Molecular Teratology (BDRA) serves as
a forum for original scientific articles and commentary that contribute substantively to the elucidation
of the causative factors and mechanisms leading to adverse pregnancy outcomes in the human population,
including pregnancy loss, structural birth defects, and developmental disabilities. To achieve this
end, BDRA will publish research that 1) describes adverse pregnancy outcomes as a function of
developmental insult with environmental factors (here broadly defined), including clinical and epidemiologic
studies to determine important exposures, genes, and pathways that underlie teratogenic effects; 2) analyzes
critical events in standard and novel animal models using modern tools of cellular or molecular biology,
biochemistry and structural biology, experimental embryology and developmental physiology, genetics, and
genomics/proteomics/metabolomics (e.g., biomics) to define the processes of normal and abnormal development;
3) predicts adverse developmental outcomes through generation, integration, and use of genomic/proteomic
databases, computer simulations and modeling, and analytical contributions to the compendium for biomics
in birth defects research; and 4) develops and critically evaluates approaches to the prevention of birth
defects, including new approaches for risk assessment and the clinical counseling regarding teratogenic
agents.
This virtual issue of BDRA highlights several recently published articles that convey the breadth of research that this journal seeks to publish. The focus of these articles ranges from molecular epidemiology (Manson and Carr, and Shi et al.) to molecular teratology (Collier et al., Hansen et al, Tang and Finnell). The Diglio et al. article brings molecular epidemiology and teratology together to hypothesize that perturbations in sonic hedgehog signaling play a role in Smith-Lemli-Opiz syndrome.
We invite you to peruse these selected articles to learn more about the exciting field of birth defects research.
These articles are provided free online by Wiley-Liss, Inc., the publishers of Birth Defects Research, as a service to the scientific community.
Birth Defects Research Part A - Special On-Line Issue:
Molecular Approaches to the Study of Birth Defects
Original Articles
Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors
Jeanne M. Manson, Michael C. Carr
Birth Defects Research (Part A), Volume 67, Issue 10, pp.825-836.
View Abstract | Full Text HTML | Full Text PDF (Size: 209K)
Selection of normalizer genes in conducting relative gene expression analysis of embryos
Qin J. Zhang, Antony Chadderton, Robert L. Clark, Karen A. Augustine-Rauch
Birth Defects Research (Part A), Volume 67, Issue 8, pp.533-544.
View Abstract | Full Text HTML | Full Text PDF (Size: 593K)
Genotype frequencies and linkage disequilibrium in the CEPH human diversity panel for variants in folate pathway genes MTHFR, MTHFD, MTRR, RFC1, and GCP2
Min Shi, Diana Caprau, Paul Romitti, Kaare Christensen, Jeffrey C. Murray
Birth Defects Research (Part A), Volume 67, Issue 8, pp.545-549.
View Abstract | Full Text HTML | Full Text PDF (Size: 85K)
Antisense modulation of the coding or regulatory sequence of the folate receptor (folate binding protein-1) in mouse embryos leads to neural tube defects
Deborah K. Hansen, Randal D. Streck, Asok C. Antony
Birth Defects Research (Part A), Volume 67, Issue 7, pp.475-487.
View Abstract | Full Text HTML | Full Text PDF (Size: 278K)
Trichloroethylene effects on gene expression during cardiac development
J. Michael Collier, Ornella Selmin, Paula D. Johnson, Raymond B. Runyan
Birth Defects Research (Part A), Volume 67, Issue 7, pp.488-503.
View Abstract | Full Text HTML | Full Text PDF (Size: 182K)
Neural and orofacial defects in Folbp1 knockout mice
Louisa S. Tang, Richard H. Finnell
Birth Defects Research (Part A), Volume 67, Issue 4, pp.209-218.
View Abstract | Full Text HTML | Full Text PDF (Size: 630K)
Specific congenital heart defects in RSH/Smith-Lemli-Opitz syndrome: Postulated involvement of the Sonic Hedgehog pathway in syndromes with postaxial polydactyly or heterotaxia
Maria Cristina Digilio, Bruno Marino, Aldo Giannotti, Bruno Dallapiccola, John M. Opitz
Birth Defects Research (Part A), Volume 67, Issue 3, pp.149-153.
View Abstract | Full Text HTML | Full Text PDF (Size: 151K)
Page updated October 20, 2003
Wiley
Anatomy Home Page | Key
Journals | Related
Journals
Books
of Interest | Internet
Resources | Contact Us