Regulatory RNA Mini-Meeting

AAA’s Regulatory RNA Mini-meeting, part of the AAA Annual Meeting/EB 2012, is scheduled for April 23-24 in San Diego. It includes three symposia and a platform session. See links at left to register.

To see more details on the sessions listed on this page, please click on the plus (+) sign.

Cell Biology and Regulatory RNAs

Chair: Kannanganattu Prasanth (Univ. of Illinois at Urbana-Champaign)

Monday, April 23, 10:30 am - 12:30 pm

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Eukaryotic genome harbors a large number of non-protein coding RNAs (ncRNAs). Recent studies have demonstrated the involvement of ncRNAs in several vital functions, including cellular proliferation, differentiation, and apoptosis and their aberrant expression have been correlated in several diseases. Thus far, our understanding about the roles of ncRNAs and their relevance in disease pathways is only “the tip of an iceberg.”  It will therefore be crucial to unravel the functions for the vast number of ncRNAs buried within the eukaryotic genome. This symposium will discuss the roles of disease-associated ncRNAs and how they regulate key cellular processes.

  • Gordon Carmichael (Univ. of Connecticut Health Center)
    A New Class of Intron-derived Long Noncoding RNAs
  • Kannanganattu Prasanth (Univ. of Illinois at Urbana-Champaign)
    Role of Cancer-associated Nuclear-retained RNA in Pre-mRNA Splicing Regulation
  • Ashish Lal (National Cancer Institute, NIH)
    A MicroRNA Pulldown Approach Uncovers Regulation of p53 Activity and Growth Factor Signaling by miR-34a
  • Jeanne Lawrence (Univ. of Massachusetts Medical School)
    Repeat RNAs in Chromosome Regulation and Mis-Regulation in Cancer

Epigenetics and Regulatory RNAs [Platform Session]

Chair: Bernard Futscher (Univ. of Arizona)

Tuesday, April 24, 8:00 am - 10:00 am

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  • Yanhua Xu (UCSF)

    Modulation of Shh Signaling by MicroRNAs

  • Michael Lam (UC San Diego)

    Negative Regulation of Enhancer-associated RNA in Macrophages

  • Kevin Morris (The Scripps Research Institute)
    Non-coding RNAs: Epigenetic Regulators of Gene Transcription in Human Cells
  • Josef Wissler (ARCONS Institute for Applied Research & Didactics)
    Vascular Epigenetics by Regulatory RNA: Chance and Necessity [Algorithms] in Adaptation Reactions
  • Claes Wahlestedt (Univ. of Miami Miller School of Medicine)
    Epigenomic Implications of Antisense Transcription
  • Michael Rosenfeld (UCSD/HHMI)
    ncRNAs, Subnuclear Architecture, and Relocation of Regulated Transcription Units: A Strategy for Controlling Regulated Gene Programs in the Three-dimensional Space of the Nucleus

MicroRNAs in Cardiac Development and Disease

Chair: Da-Zhi Wang (Boston Children's Hospital/Harvard Medical School)

Tuesday, April 24, 10:30 am - 12:30 pm

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Recent studies have discovered novel and unexpected roles for microRNAs (miRNAs), which are small, non-coding, endogenously conserved RNAs. MicroRNAs typically act post-transcriptionally to repress target gene expression and have been estimated to affect most of the genome.  They modulate cell growth and differentiation, signal transduction, organ development, and cell lineage specification, among others.  MicroRNAs are expressed in the cardiovascular system and play a critical role in the development and function of the heart. We will discuss the novel molecular mechanisms of the miRNA-mediated regulatory network in heart development and the new opportunities for therapeutic intervention for cardiovascular disease.

  • Da-Zhi Wang (Boston Children's Hospital/Harvard Medical School)
    MicroRNAs in Cardiac and Skeletal Muscle
  • Deepak Srivastava (Univ. of California, San Francisco)
    MicroRNA-Transcriptional Regulatory Networks in Cardiovascular Differentiation
  • J. David Port (Univ. of Colorado Health Sciences Center)
    MicroRNA Expression in Heart Failure
  • Gerald W. Dorn (Washington Univ.)
    MicroRNAs and Heart Remodeling

MicroRNAs in Stem Cells and Cancer

Chair: Rebecca Hartley (Univ. of New Mexico)

Monday, April 23, 8:00 am - 10:00 am

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Non-coding RNAs have emerged as key regulators of both development and disease. This symposium will bring together leaders in the fields of noncoding RNA regulation of early development and noncoding RNA deregulation in cancer. Speakers will focus on how early embryos become competent for RNAi, how noncoding RNAs regulate stem cell function, miRNA regulation of the DNA damage response, and noncoding RNAs as therapeutic targets in cancer.

  • Robert Blelloch (Univ. of California, San Francisco)
    MicroRNAs to Pathways in Stem Cells and Cancer
  • Michael Sheets (Univ. of Wisconsin Medical School)
    Enabling Xenopus Oocytes and Embryos to Perform RNAi
  • Rebecca Hartley (Univ. of New Mexico)
    MicroRNA-RNA Binding Protein Face Off in Cancer
  • George Carlin (Univ. of Texas/MD Anderson Cancer Center)
    Noncoding RNAs: From Scientist to Patient and Back
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