AAA 2012 Scientific Sessions

To see more details on the sessions listed on this page, please click on the plus (+) sign.

Adult Stem Cells: From Basic Research to Clinical Applications

Chair: Mari Dezawa (Tohoku Univ. Grad. School of Medicine)

Tuesday, April 24, 8:00 am - 10:00 am

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Co-sponsored by The Anatomical Record


Cell transplantation is a strategy with great potential for the treatment of many diseases, and several stem cell types are considered candidates for transplantation therapy. Mesenchymal stem cells are an invaluable therapeutic cell source because they are easy to access and can be expanded from patients or donor mesenchymal tissues without posing serious ethical and technical problems. These cells can also be transplanted with a low risk of tumorigenesis. Mesenchymal stem cells have a variety of actions, e.g., trophic effects for protecting damaged tissues, ability to differentiate into a broad spectrum of cells to contribute to the replenishment of lost cells in damaged tissues, and the ability to suppress immunologic reactions, known as immunomodulation.  The complete picture of the diverse actions of mesenchymal stem cells, however, remains an enigma.  In this symposium, we discuss recent advances in the basic research of mesenchymal stem cells with a special focus on practical issues related to the clinical applicability of these cells.

  • Darwin Prockop (Institute for Regenerative Medicine,Texas A&M Health Science Center)
    Potential Therapies with Adult Stem/Progenitor Cells from Bone Marrow (MSCs) and the Proteins They Produce in Response to Injuries from Injured Tissues
  • Katsuto Tamai (Osaka Univ.)
    Development of Regeneration-inducing Medicine Based on Cross Talk Between Injured Tissue and Bone Marrow
  • Kenneth Giacin (Stemcyte)
    The Present and Future of Stem Cell Therapies
  • Mari Dezawa (Tohoku Univ)
    Muse Cells: A Novel Type of Adult Human Pluripotent Stem Cells in Mesenchymal Tissues and their Contribution to Tissue Repair

Bioengineering Principles during Development [Hybrid Symposium]

Chair: Elizabeth Jones (McGill Univ.)

Wednesday, April 25, 8:00 am - 10:00 am

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The aim of this session is to explore both how engineering can be used to study developmental biology and to ask how developmental biology can be used in engineering. Bioengineering research encompasses a variety of fields including biological flows, biological physics, tissue engineering and computation modeling.  This session encompasses subjects such as mechanical aspects of development and computational modeling of development, but also extends to application of embryology to design of tissue constructs and development of new technologies.

 

Alison McGuigan (Univ. of Toronto)
  Designing In Vitro Tools to Pattern Gene Expression using Inducible Gene Expression
Elizabeth Jones (McGill Univ.)
  Ontogeny of Mechanosensation during Vascular Development

  • Michelle Sukup Jackson (MIT)
    Visualizing Homologous Recombination and Illustrating DNA Repair Pathway Interaction In Vivo via a Bioengineered Fluorescent Reporter System
  • Tamara Franz-Odendaal (Mount Saint Vincent Univ.)
    Exposure to Simulated Microgravity Affects Development of the Skull in Danio Rerio
  • Chuansen Zhang (Second Military Medical Univ.)
    Create an Engineered Conduction Tissue by Seeding Cardiac Progenitor Cells on Gelatin Foam
  • Eliska Krejci (Academy of Sciences of the Czech Republic)
    FGF Signaling is Involved in Physiological Adaptation to Pressure Overload in Developing Heart

Cardiac Tissue Engineering

Chair: Gordana Vunjak-Novakovic (Columbia Univ.)

Wednesday, April 25, 10:30 am - 12:30 pm

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  • Joseph Wu (Stanford Univ. School of Medicine)
    Clinically Relevant Issues in Cardiac Stem Cell Therapy
  • Milica Radisic (Univ. of Toronto)
    In Vitro Models of Heart Disease and Regeneration
  • Narine Sarvazyan (George Washington Univ.)
    Functional Imaging of Signal Propagation in Native and Engineered Myocardium
  • Gordana Vunjak-Novakovic (Columbia Univ.)
    Myocardial Regeneration through Tissue Engineering

Craniofacial Birth Defects

Chair: L. Bruno Ruest (Baylor College of Dentistry)

Tuesday, April 24, 8:00 am - 10:00 am

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Co-sponsored by AAA’s Advisory Committee for Young Anatomists


This symposium offers a platform for the presentation of both clinical and basic cutting edge research on craniofacial development with a focus on the correlation between the anatomical defects observed in human anomalies and the genetics, cellular, or molecular pathways that may be involved in these syndromic and non-syndromic birth defects.

  • Alex Vieira (Univ. of Pittsburgh)
    Redefining Cleft Lip and Palate
  • Brad Amendt (Texas A&M Health Science Center-Houston)
    A Role for MicroRNAs in Axenfeld Rieger Syndrome and Craniofacial/Tooth Anomalies
  • Lisa Taneyhill (Univ. of Maryland)
    The Role of Cellular Junctions in Neural Crest Cell Emigration
  • L. Bruno Ruest (Baylor College of Dentistry)
    TWISTing a Hand on the Mandible

Digital Imaging

Chair: Shao-Xiang Zhang (Third Military Medical Univ.)

Saturday, April 21, 3:30 pm - 5:30 pm

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Sponsored by CSAS and AAA

Digital imaging has become an important tool in both biomedical research and education.  This session, sponsored by the Chinese Society of Anatomical Sciences and the AAA, will present work applying digital imaging to better understand developmental changes and to determine morphological parameters to guide surgical and other medical procedures.  The history and development of both the Chinese Visible Human Project and the US sponsored Virtual Human Embryo Project and their potential utility in biomedical research and in surgical and educational applications will also be discussed.

  • Shuwei Liu (Shandong Univ. School of Medicine)
    The Shape, Size, and Asymmetry of Fetal Hippocampal Formation during the Second Trimester
  • Jun Ouyang (Southern Medical Univ.)
    Three-dimensional Reconstruction and Measurement of Cervical Vertebral CT Images: Anatomical Bases for Cervical Anterior Transpediular Screw Fixation
  • Shao-Xiang Zhang (Third Military Medical Univ.)
    Chinese Visible Human Project and Its Application
  • John Cork LSU Health Sciences Center
    The Virtual Human Embryo Project: A Resource for the Study of Human Embryology

Diseases of the Nervous System

Chair: Yun-Qing Li (The Fourth Military Medical Univ.)

Tuesday, April 24, 2:30 pm - 4:30 pm

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Sponsored by CSAS and AAA

The nervous system is a dynamic organ, prone to injury and degeneration. Its complexity renders efforts to repair injuries difficult.  Tissue engineering and stem cells have the potential to alleviate some of these challenges. This session, sponsored by the Chinese Society of Anatomical Sciences together with AAA, will explore conditions such as stroke, allergic encephalomyelitis (EAE) and focal ischemia. The speakers will discuss mediators of autophagy and apoptosis during focal ischemia; describe an animal model for allergic encephalomyelitis (EAE); and the role of a Didox in inhibiting the progression of EAE. The potential of stem cell tissue engineering in individuals with stroke and the role of endomorphin in antinociception will also be discussed.

  • Changman Zhou (Peking Univ. Health Science Center)
    TMEM166, a Transmembrane Protein, Regulates Cell Autophagy and Apoptosis in Focal Ferebral Ischemia
  • Qunyuan Xu (Beijing Institute for Neuroscience, Capital Medical Univ.)
    The Experimental Therapy of Brain Injury by Tissue Engineering with Hyaluronic Acid Based Scaffold
  • Yun-Qing Li (The Fourth Military Medical Univ.)
    Mechanisms Underlying Antinociception Exerted by Endomorphin in the Spinal Dorsal Horn
  • George DeVries (McGuire VA Medical Center)
    Didox - A Multipotent Drug for Treating Demyelinating Disease

Epigenetic Plasticity in Health and Disease [Hybrid Symposium]

Chair: Frederick Domann (Univ. of Iowa)

Sunday, April 22, 2:30 pm - 4:30 pm

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At the 10-year anniversary of the sequencing of the human genome, the epigenetic control mechanisms that render DNA sequences available for transcription in a normal cell type specific fashion are just beginning to be appreciated.  A deeper and clearer understanding of the establishment and maintenance of normal epigenetic landscapes is vital to understanding the function of the human genome in health and disease.  Epigenomics has been, and remains, on the NIH Roadmap of important areas of biomedical investigation with respect to human health.  This hybrid symposium will focus on fundamental epigenetic processes in human health and disease.

 

 • Bernard Futscher (Univ. of Arizona)
   The Epigenetic Basis of Cell Type Specificity
 • Frederick Domann (Univ. of Iowa)
   Metabolic Regulation of Epigenetic Process

  • David Armstrong (Queen’s Univ.)
    Loss of Maternal Atrial Natriuretic Peptide Programs Cardiac and Renal Gene Expression: Role of GATA4 and Npr-1 in the Fetal Programming of Cardiovascular Health and Disease
  • Christopher Wendler (Yale Univ.)
    Embryonic Caffeine Acts via A1 Adenosine Receptors to Induce Adverse Effects in Adulthood
  • Saori Taniguchi (California State Univ., Long Beach)
    Age-dependent Expression of Retinoic Acid-related Orphan Receptor-alpha (Rora) in the Developing Mouse Cortex and Hippocampus
  • Nandhini Kanagaraj (National Univ. of Singapore)
    MicroRNA-124 and Its Target Gene are altered in the Substantia Nigra (SNc) of the Brain of MPTP- mouse Model of Parkinson’s Disease

Excellence in Canadian Research – Neural Regeneration

Chair: Michael Kawaja (Queen's Univ.)

Monday, April 23, 2:30 pm - 4:30 pm

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Co-sponsored by Canadian Association for Anatomy, Neurobiology & Cell Biology

 

Since the seminal experiments by Ramon y Cajal, neuroscientists have faced a tremendous obstacle in stimulating the central nervous system of adult mammals to regenerate after trauma, both structurally and functionally.  It is now appreciated that central neurons are, in fact, capable of substantial regrowth of severed axons. It is, however, the damaged central environment that poses many challenges to replacing the lost neurons and oligodendrocytes, as well as for the sustained elongation of regenerating axons.  The damaged central environment can be modified by 1) the implantation of exogenous cells, 2) the activation of endogenous progenitor cells, 3) the alteration of neuronal receptors for growth factors, and/or 4) the neutralization of inhibitory extracellular matrix molecules.  All of these experimental strategies have yielded beneficial outcomes regarding the successful regeneration of the damaged brain and spinal cord.  Speakers in this symposium, all of whom hail from Canada, will discuss their recent findings in the field of neural regeneration.  This session will highlight the challenges and successes regarding neural cell replacement and the regrowth of severed axons in the central nervous system of adult mammals.

  • Soheila Karimi (Univ. of Manitoba)
    The Role of Microenvironment on the Regenerative Potential of Neural Stem Cells after Spinal Cord Injury
  • Cindi Morshead (Univ. of Toronto)
    Neural Stem Cells: From Basic Biology to Tissue Repair
  • Adriana Di Polo (Univ. de Montréal)
    Restoration of Retinal Ganglion Cell Dendritic Arbors after Axonal Injury In Vivo
  • Victor Rafuse (Dalhousie Univ.)
    Stem Cell-derived Motoneurons: Tools for Studying Motoneuron Disease and Motoneuron Development

The Exquisite, Little Brains of Big Insects

Chair: John Hildebrand (Univ. of Arizona)

Monday, April 23, 10:30 am - 12:30 pm

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A long and productive tradition of comparative research on the nervous systems of invertebrates has contributed greatly to our understanding of the functional organization, development, and evolution of nervous systems and neural mechanisms underlying behavior. Insects in particular offer powerful experimental model systems. Today, the most prominent example is the fruit fly, Drosophila melanogaster, whose genetic and genomic advantages attract many investigators, but whose small size is limiting for some kinds of research. This session focuses on much larger insects with beautiful and experimentally tractable nervous systems that permit investigations that complement and extend those accomplished with diminutive species.

  • Nicholas Strausfeld (Univ. of Arizona)
    The Evolution of Insect Brains and Why Big May Be Better
  • Susan Fahrbach (Wake Forest Univ.)
    Regulation of Form and Function in the Nervous System of Honey Bees
  • Elke Buschbeck (Univ. of Cincinnati)
    Evolution and Specializations of Insect Eyes: Twisted-wing Insects and Larval Diving Beetles
  • John Hildebrand (Univ. of Arizona)
    Learning from Insect Brains: CNS Processing of Behaviorally Significant Odors

Global Positioning Systems Guide Neuronal Migration and Synapse Formation [Hybrid Symposium]

Chair: Alexis Stranahan (Georgia Health Sciences Univ.)

Sunday, April 22, 2:30 pm - 4:30 pm

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Supported by an educational grant from Springer

 

The developing brain is formed through an orchestrated pattern of neuronal migration, leading to the formation of heterogeneous functional regions in the adult. Several essential proteins and pathways have been identified as mediators of developmental neuronal migration and cell positioning. However, these proteins and pathways do not cease to be functionally relevant after the embryonic and early postnatal period; instead, they switch from guiding cells, to guiding synapses. The vast majority of synapses in the adult brain are formed on dendritic spines, which are small, motile membrane protrusions that occur at intervals along neuronal dendritic processes. The number and morphology of spines and synapses fluctuates with environmental experience and synaptic activity, and many of the molecular guidance cues that mediate cell migration transition to a role in synapse formation and plasticity in the adult. The outcome of synaptic guidance determines the strength and plasticity of neuronal networks. Speakers will describe the contributions of signaling pathways traditionally associated with neuronal development to plasticity in the adult and aging brain.

 

 • Nibaldo Inestrosa (Pontifica Catholic Univ.)
   Activation of Brain Wnt Signaling In Vivo: Effect on LTP and Neurogenesis

  • Lavinia Alberi (Univ. of Fribourg)
    Notch1 Ablation Induces Molecular Changes in Plasticity Genes that Contribute to Memory Formation
  • Alexis Stranahan (Georgia Health Sciences Univ.)
    Reelin Signaling in the Hippocampus and Entorhinal Cortex Contributes to Age-related Alterations in Cognitive Function
  • Matthew Zabel (Loma Linda Univ.)
    Switch in Amyloid Clearance Mechanisms Leads to Vascular Fragility in Cerebral Amyloid Angiopathy
  • Mason Shaner (Univ. of California, San Diego)
    The Death of Neurons Derived from Familial Alzheimer’s Disease Pluripotent Stem Cells is no Different from the Death of Neurons Derived from Normal Controls

Lung Development and the Origins of Disease

Chair: David Ornitz (Washington Univ.)

Monday, April 23, 2:30 pm - 4:30 pm

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Co-sponsored by Developmental Dynamics

 

Lung disease is the fourth leading cause of death and disability in the United States. The etiology of lung disease often begins during embryonic development or early in life. Knowledge of the molecular, cellular, and genetic mechanisms that orchestrate lung development are required to understand the pathogenesis of genetic, developmental, and acquired lung disease, to develop diagnostic criteria for these diseases, and to develop rational therapies.  In this symposium, we will discuss signaling pathways that regulate lung development, how disruption of these pathways can lead to lung disease, and how these pathways may be used to promote lung regeneration.

  • Xin Sun (Univ. of Wisconsin-Madison)
    The Role of Slit-robo Signaling in Congenital Diaphragmatic Hernia
  • David Warburton (Saban Research Institute/Children’s Hospital Los Angeles)
    Lung Developmental Biology: An Important Key to Regeneration in Apparently Adult Onset Disease
  • Ed Morrisey (Univ. of Pennsylvania)
    Transcriptional and Epigenetic Regulation of Lung Development and Regeneration
  • David Ornitz (Washington Univ.)
    Growth Factor Signaling Pathways in Lung Development and Cancer

Morphometry and Applied Anatomy

Chair: Richard Halti Cabral (Metropolitan Univ. of Santos)

Sunday, April 22, 2:30 pm - 4:30 pm

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Sponsored by SBA and AAA

In the Morphometry and Applied Anatomy session, jointly sponsored by the Sociedade Brasileira de Anatomia and the AAA, speakers will discuss their work evaluating morphological features and parameters that can be used to guide and assess clinical interventions and diagnoses.  These studies include an assessment of various techniques to evaluate peripheral neuropathies; analysis of the morphological features associated with the development of myocardial bridges and determination of the efficacy of different vascular grafts for myocardial revascularization and peritoneal grafts for tendon replacement.

  • Valéria Paula Sassoli Fazan (University of São Paulo)
    Peripheral Nerve Morphometry: From Neurosciences to Clinical Applications
  • Telma Sumie Masuko (Federal Univ. of Bahia)
    Ultrastructural Analysis of Experimental Tenoplasty Using Bovine Peritoneum
  • Nadir Eunice Valverde Barbato de Prates (Univ. of São Paulo)
    Myocardial Bridges: From Anatomy to Clinical Practice
  • Richard Halti Cabral (Metropolitan Univ. of Santos)
    Clinical Significance of Organs Vascularization

Novel Views of the Eye

Chair: John Clark (Univ. of Washington)

Wednesday, April 25, 10:30 am - 12:30 pm

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Co-sponsored by the Association of Anatomy, Cell Biology & Neurobiology Chairpersons

 

Some of the most dramatic advances in basic science research are in vision sciences.  This session summarizes successful genetic approaches to visual disorder, advances in small stress proteins that can protect against molecular aging and the fundamental structure of specialized beaded filaments found in lens. We look forward to "seeing" you there.

  • Paul Fitzgerald (Univ. of California, Davis)
    The Function of Ocular Lens Intermediate Filaments in Normal and Pathogenic Biology
  • Jay Neitz (Univ. of Washington)
    The Genetic Basis for Normal Vision and Vision Disorders
  • Maureen Neitz (Univ. of Washington)
    Gene Therapy as a Cure for Color Blindness
  • John Clark (Univ. of Washington)
    Protection against Molecular Aging and Degeneration

Reactivation of Embryonic Processes in Regeneration & Repair

Chair: Martine Dunnwald (Univ. of Iowa) &
Jill Helms (Stanford Univ.)
Monday, April 23, 10:30 am - 12:30 pm

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Although they occur at different ends of the life spectrum, embryonic tissue development and adult wound repair share a remarkable number of similarities: molecules, cells, and mechanisms controlling the formation of tissues in an embryo are the same as the molecules and mechanisms activated after injury. There is one big difference: the time scale and the extent/distribution of tissue-forming activity. Come and listen to outstanding speakers talking about their research using a variety of models (flies, mice, human) that illustrate the conservative nature of biology.  In the end, “development” and “wound repair” are just two sides of the same coin.

  • William McGinnis (Univ. of California, San Diego)
    Regeneration of the Drosophila Epidermal Barrier after Wounding
  • Paul Sharpe (King’s College London)
    Mesenchymal Stem Cell Miches in Tooth Growth and Repair
  • Jill Helms (Stanford Univ.)
    Translating Insights from Development into Regenerative Medicine with a Focus on Wnt Biology
  • Martine Dunnwald (Univ. of Iowa)
    Interferon Regulatory Factor 6: A Novel Transcriptional Regulator of Embryonic Development and Wound Healing

Stem Cell Biology

Chair: Chunhua Zhao (Chinese Academy of Medical Sciences & Peking Union Medical College)

Tuesday, April 24, 10:30 am - 12:30 pm

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Sponsored by CSAS and AAA

Stem cells in adult tissues have the capacity to self-renew and generate differentiated progeny that replenish lost or damaged cells. The balance between stem cell self-renewal and differentiation is coordinated by intrinsic factors and extrinsic signals.  In this session, sponsored by the Chinese Society of Anatomical Sciences together with AAA, the regulation of stem cell properties and their capacity for repair will be explored. A primary focus will be the role of intrinsic histone methylation in the maintenance of mesenchymal and ovarian stem cells. This will be complemented by discussion of the extrinsic role of integrin signaling and neural scaffolds in the pathogenesis of cancer and repair of neural injury.

  • Hongquan Zhang (Peking Univ. Health Science Center)
    Role of an Integrin-interacting Protein in the Control of EMT in Cancer and Fibrosis
  • Yuan-shan Zeng (Sun Yat-sen Univ.)
    Artificial Neural Network Scaffold Transplanted Promotes the Recovery of Structure and Function after Rat Spinal Cord Transection
  • Chunhua Zhao (Chinese Academy of Medical Sciences & Peking Union Medical College)
    Histone Methylation and MicroRNA Mediated Regulation of the Multipotential State of Flk1+ Mesenchymal Stem Cells
  • Ting Xie (Stowers Institute for Medical Research)
    Intrinsic and Extrinsic Control of the Balance between Stem Cell Self-Renewal and Differentiation

The Nucleus: New Insights and Understanding

Chair: Mark Alliegro (Marine Biological Laboratory)

Monday, April 23, 8:00 am - 10:00 am

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Supported by an educational grant from Hamilton Thorne, Inc.

 

Our knowledge of the cell nucleus stands on the edge of significant advance.  Subjects that were once controversial are moving toward resolution.  Others that couldn't have been controversial, simply for lack of data, are coming to light.  This symposium will address four topics impacting our understanding of nuclear structure, physiology, and evolutionary origin: (1) the nucleolinus, a little known compartment thought by early investigators to play a role in cell division; (2) the plurifunctional nucleolus, covering new and surprising functions of a compartment previously thought to be well understood; (3) unexpected roles of nuclear lamins and how hundreds of disease-causing mutations are providing original insights into alternative lamin functions; and (4) new insights on the evolution of the nucleus and the role played by symbiosis in the origin of eukaryotes.  This session promises to have participants saying to themselves and to each other, "I didn't know that!"

  • Mark Alliegro (Marine Biological Laboratory)
    The Nucleolinus: A Disappearing, Forgotten, and (Maybe) Misnamed Organelle
  • Thoru Pederson (Univ. of Massachusetts Medical School)
    The Expanded Repertoire of a Classical Intranuclear Domain
  • Robert Goldman (Northwestern Univ.)
    The Lamins are Major Determinants of Nuclear Architecture
  • James Lake (UCLA)
    The Evolution of the Nucleus

The Role of Variation during Morphogenesis in Evolution and Disease

Chair: Benedikt Hallgrimsson (Univ. of Calgary) &
Ralph Marcucio (UCSF)
Tuesday, April 24, 10:30 am - 12:30 pm

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Developmental biology has only recently begun to focus on the mechanisms that generate variation within species.  This is a difficult topic about which very little is known. Recent work has begun to reveal the mechanistic basis for continuous phenotypic variation in both biomedical and evolutionary contexts.  This symposium brings together speakers who study the developmental determinants of variation in the craniofacial complex and the vertebrate limb from both an evolutionary and biomedical perspective. The intent is to explore the potential commonality of mechanisms that underlie the generation of the phenotypic variation in evolution and disease.

  • Joan Richtsmeier (Penn State)
    Making a Head: Diverse Craniofacial Outcomes in Disease
  • Ralph Marcucio (UCSF)
    Tissue Interactions that Regulate Facial Morphogenesis
  • James Sharpe (Centre de Regulacio Genomica)
    In-silico Organogenesis: Measuring and Modelling Vertebrate Limb Development
  • Benedikt Hallgrimsson (Univ. of Calgary)
    The Phenogenomics of Craniofacial Shape

Visualizing Complex Biomedical Systems

Chair: Christopher Johnson (Univ. of Utah)

Saturday, April 21, 1:00 pm - 3:00 pm

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Advances in computational modeling, imaging, and simulation allow researchers to build and test models of increasingly complex phenomena and thus to generate unprecedented amounts of data. These advances have created the need to make corresponding progress in our ability to understand large amounts of data and information arising from multiple sources. In fact, to effectively understand and make use of the vast amounts of information being produced is one of the greatest scientific challenges of the 21st century.  Visualization, namely helping researchers explore measured or simulated data to gain insight into structures and relationships within the data, will be critical in achieving this goal and is fundamental to understanding models of complex phenomena.  Each speaker will introduce new visualization techniques and software that can help gain insight into large-scale and often complex data.

  • Christopher Johnson (Univ. of Utah)
    Image-Based Biomedical Modeling, Simulation, and Visualization
  • Raghu Machiraju (The Ohio State Univ.)
    Quantitative Cellular Phenotyping in Tissue Microenvironments
  • Chandrajit Bajaj (Univ. of Texas at Austin)
    Automating the Visualization of Biological Machines
  • Ron Kikinis (Brigham & Women's Hospital)
    3D Slicer

Vascular Endothelium in Health and Disease

Chair: Bjorn Olson (Harvard School of Dental Medicine)

Sunday, April 22, 10:30 a.m. - 12:30 p.m.

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Henry Gray/Lippincott Williams & Wilkins Scientific Achievement Award Symposium

 

This interdisciplinary symposium covers recent research on vascular endothelial functions in health and disease.  The topics include cellular and molecular mechanisms responsible for regulation of vascular morphogenesis, endothelial-macrophage interactions in the control of vascular permeability, the role of angiogenesis and endothelial functions in bone development and repair, and the genetic and cellular basis for vascular anomalies.

  • Luisa Iruela-Arispe (UCLA)
    Differences in VEGF Signaling in Health and Disease
  • Alessandro Fantin (Univ. College London)
    Novel Mechanisms in Vascular Permeability
  • Thomas Clemens (Johns Hopkins Univ.)
    Targeting Angiogenesis for Bone Repair
  • Miikka Vikkula (Univ. catholique de Louvain)
    Venous Malformations: From Causes to Pathogenic Mechanisms and Murine Models

Tissue Engineering, Regeneration & Repair [Platform Session]

Chair: Ralph Marcucio (UCSF)

Monday, April 23, 8:00 am – 10:00 am

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Nicolas L'Heureux (Cytograft Tissue Engineering)

Developing a Completely Biological Tissue-engineered Blood Vessel for Clinical Use
Margaret McNulty (Rush Univ. Medical Center)
Adult Stem Cell Mobilization to Enhance Intramembranous Bone Regeneration in the Mouse
Karen Christman (UC San Diego)
Injectable Extracellular Matrix Derived Hydrogel for Cardiac Repair
David Burmeister (Wake Forest Univ.)
Age-dependent Impairments in Rat Bladder Regeneration
Rohan Balkawade (Louisiana Tech Univ.)
Bioactive Nanomaterials for Enhanced Wound Healing
Chelsea Bahney (Univ. of California, San Fancisco)
Tissue Engineering Bone by Recapitulating Developmental and Repair Programs offers Improved Biological Outcomes
Xiaohua Liu (Baylor College of Dentistry)
Nano-fibrous Microspheres with Sustained Growth Factor Delivery for Bone Regeneration
Kurt Hankenson (Univ. of Pennsylvania)
Notch Signaling through the Jagged-1 Ligand Regulates Mesenchymal Progenitor Differentiation and Tissue Regeneration

Cardiovascular Biology [Platform Session]

Chair: Joey Barnett (Vanderbilt Univ. Med Center)

Monday, April 23, 2:30 pm – 4:30 pm

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Jeffrey Spees (Univ. of Vermont)
Secreted Growth Factors from Human Epicardial-derived Precursor Cells Protect against Progressive Injury after Myocardial Ischemia with Reperfusion by Preventing Vascular Rhexis
Jiayi Tao (Case Western Reserve Univ.)
Epicardial HIF1 Regulates Vascular Precursor Cell Invasion into the Myocardium through the VEGF Signaling Pathway
Katja Schenke-Layland (Fraunhofer IGB Stuttgart)
VEGF Receptors Identify a Multipotent Cardiovascular Progenitor Cell in Developing Hearts and Induced Pluripotent Stem Cells
Chuansen Zhang (The Second Military Medical Univ.)
Bone Marrow-derived Multipotent Adult Progenitor Cells are Capable of Functional Sinus Node Myocytes Differentiation
Stacey Rentschler (Univ. of Pennsylvania)
Myocardial Notch Signaling Reprograms Cardiomyoctes to a Conduction-like Phenotype
Arunima Sengupta (Cincinnati Children's Medical Hospital Center)
FOXO Transcription Factors are Critical regulators of Neonatal Cardiomyocyte Proliferation
Peggi Angel (Vanderbilt Univ.)
Integrating MALDI Imaging Mass Spectrometry and Shotgun Proteomics for a Systems Biology Understanding of Congenital Heart Valve Disease
Brenda Rongish (Univ. of Kansas Medical Center)
Dynamic Imaging of VEGF Relative to the ECM and its Effects on Endocardial Cell Behavior during Cardiovascular Morphogenesis

Development & Growth [Platform Session]

Chair: Paul Trainor (Stowers Institute for Medical Research)

Tuesday, April 24, 2:30 pm – 4:30 pm

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Radek Sindelka (Whitehead Institute for Biomedical Research)
A Novel Kinin-kallikrein Pathway Regulates Vertebrate Mouth Formation
Xin Li (UCSF)
A Novel Gene Crispld2 may Contribute to Facial Dysmophology in a Chicken Model of Crouzon’s Syndrome
Kateryna Kyrylkova (Oregon State Univ.)
The Role of the Transcription Factor BCL11B in the Regulation of Growth and Asymmetric Development of the Mouse Incisor
Lisa Sandell (Univ. of Louisville)
Regulated Metabolism of Vitamin A by Retinol Dehydrogenase 10 is Critical for Embryonic Development of the Heart
Thomas Cunningham (Sanford Burnham Medical Research Institute)
Retinoic Acid Antagonism of Fgf8 during Forelimb Development
Cecilia Gouveia (Institute of Biomedical Sciences, Univ. of Sao Paulo)
Alpha2A and Alpha2C Adrenergic Receptors are Involved in the Regulation of Bone Growth, Structure and Function
Lisa Cooper (Univ. of Illinois)
Cellular Patterns of Bat (Carollia) Forelimb Skeletogenesis and their Biomechanical Consequences

Form, Function & Evolution [Platform Session]

Chair: Kathleen Muldoon (Dartmouth Medical School)

Wednesday, April 25, 8:00 am – 10:00 am

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Heather Ahrens (Johns Hopkins Univ. School of Medicine)
A Morphometric Study of Phylogenetic and Ecologic Patterns in Procyonid (Mammalia: Carnivora) Endocasts
Megan Holmes (Johns Hopkins School of Medicine)
Molar Surface Area and Mandibular Mechanics: Complex Scaling Relationships in Primate Masticatory Systems
Amy Mork (Northeastern Ohio Medical Univ.)
Comparative Analysis of Masticatory Apparatus Features in Neonatal Common Marmosets (Callithrix Jacchus) and Cotton-top Tamarins (Saguinus Oedipus)
Tony Adar (SUNY Downstate Medical Center)
Endoscopic Investigation of the Palatopharyngeal Muscular Anatomy of the Great Apes: Anatomic Models for the Study of Obstructive Sleep Apnea Etiology
Michelle Osborn (Louisiana State Univ.)
Comparative Functional Morphology of the Head Suspension of Quadrupedal Cats and the Shoulder Suspension of Bipedal Humans
Georgina Voegele (Johns Hopkins School of Medicine)
The Trapezius Complex in Mammalia
Kirsten Brown (The George Washington Univ. School of Medicine and Health Sciences)
Decoupling of Sexual Dimorphism in the Human Bony Pelvis and its Relationship to Differential Selective Pressures
Nicole Reeves (Univ. of Tennessee)
Exceeding Expectations: Examining the Systemic Effects of High Body Mass in Relation to Mechanical Loading

Muscles & Bones: Evolution & Development [Platform Session]

Chair: Richard Schneider (Univ. of California, San Francisco)

Wednesday, April 25, 10:30 am – 12:30 pm

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Terence Capellini (Stanford Univ. School of Medicine)
When Evolution Hurts: Height, Arthritis Risk, and the Regulatory Architecture of GDF5 Function
Uriel Zapata (Eafit Univ.)
Changes in Micro-architectural Characteristics of Mandibular Sutures using Micro-CT Images in American Alligators during Ontogeny
Nadine Piekarski (Harvard-Univ.)
Neural Crest Derivation of the Bony Skull of the Mexican Axolotl
Hermann Bragulla (School of Veterinary Medicine)
Adaptations of the Musculoskeletal System in California Sea Lions to the Semi-aquatic Lifestyle
Erin Ealba (Univ. of California San Francisco)
Regulation of Jaw Size during Development and Evolution
Heather Smith (Midwestern Univ.)
A 3-D Geometric Morphometric Study of Intraspecific Variation in the Ontogeny of the Temporal Bone in Modern Homo Sapiens
Amy Merrill (Univ. of Southern California)
A Novel Skeletal Disorder Defines an Intracellular Role for FGFR2 during Development

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