Speakers: Drs. Casey Holliday and Emma Schachner
September 8, 2022
Casey Holliday is an Associate Professor in Integrative Anatomy in the Department of Pathology and Anatomical Sciences at the University of Missouri School of Medicine. Emma R. Schachner is an Associate Professor in the Department of Cell Biology and Anatomy at Louisiana State University Health Sciences Center. Drs. Holliday and Schachner are co-Guest Editors of an upcoming volume of The Anatomical Record on crocodyliform evolution, functional morphology, and paleobiology. The presentation will focus on recent advances in the biology and paleontology of this fascinating lineage of vertebrates. The presenters will discuss how researchers bring crocodylians and their extinct ancestors to life using a variety of approaches including fieldwork, imaging, 3D modeling, developmental biology, physiological monitoring, dissection, and a host of other comparative methods.
Speakers: Drs. Russell (Chip) Norris and Cortney Gensemer, Medical University of South Carolina
June 16, 2022
A not so rare whole body disease that transcends scientific and clinical specialties
The Norris lab studies connective tissue development and diseases and for the past 25 years researched the genetics of syndromic and non-syndromic cardiovascular diseases like cardiomyopathies. Recently, the Norris lab pivoted to understanding hypermobile Ehlers-Danlos syndrome (hEDS), a "not so rare" connective tissue disease that affects collagen-rich tissues. Using genome editing, mouse models of hEDS were generated to study disease initiation and progression. Guided by one of the largest clinical registries for hEDS, the Norris lab captures important clinical information and patient samples that can be used to improve diagnosis and genetic discoveries, respectively. This talk will focus primarily on background of hEDS, our recent work with hEDS and how involving patients in the research is changing the future of our understanding and treatment of this disease.
Speaker: Dr. Serjoscha Evers, SNSF Ambizione Fellow at the University of Fribourg, Switzerland
May 5, 2022
In this talk, Serjoscha will present aspects from his work on flipper evolution, the ecomorphology of the labyrinth organ, and cranial shape changes associated with diet.
Speaker: Dr. Winfried Neuhuber, Professor, University of Erlangen-Nürnberg, Institute of Anatomy and Cell Biology, Germany
March 3, 2022
Winfried Neuhuber is FAU Senior Professor of Anatomy in the Institute of Anatomy and Cell Biology at Friedrich-Alexander-Universität Erlangen Nürnberg (Germany). His research focus is on the functional anatomy of the autonomic nervous system, in particular innervation of the gastrointestinal tract using neuronal tract tracing and immunohistochemistry. In this talk, he will present some examples of organs which are targeted by both efferent and afferent vagal neurons. In contrast, he will discuss older and more recent claims of vagal innervation which most likely resulted from tracing artifacts or other misconceptions.
Speaker: David Ornitz, MD, Ph.D., Alumni Endowed Professor Washington University School of Medicine in St. Louis
February 3, 2022
David Ornitz is an Alumni Endowed Professor in the Department of Developmental Biology at Washington University School of Medicine. His research uses molecular, genetic, and biochemical approaches to study mesodermal and epithelial patterning, organogenesis, tissue homeostasis, and response to injury.
The Ornitz lab has a particular interest in the function of Fibroblast Growth Factor (FGF) signaling pathways in endochondral bone development, postnatal bone growth, and bone homeostasis. In this talk he will explore the role of an FGF receptor (FGFR) signaling center that is located in a unique perichondrial cell population that functions to regulate the activity of the adjacent growth plate.
He will then discuss studies that explore a novel role for FGFR signaling in the maintenance of osteocyte viability and skeletal homeostasis in adult mice.
Speaker: Elaine A. Ostrander, Ph.D., National Human Genome Research Institute
September 23, 2021
The Ostrander laboratory is interested in understanding the genomic factors which control the enormous amount of morphologic, disease susceptibility and behavioral variation observed in canines across the world. She has studied canine evolution, genome structure and breed formation, producing a clear understanding of how most individual breeds developed. Her most recent focus has been on morphology and evolution, as she seeks to understands the genetic underpinning of morphologic variation of canids, past and present, throughout the world.
Speaker: H. Joe Yost, Ph.D., University of Utah
August 31, 2021
The Yost laboratory seeks to understand the gene regulatory networks and developmental mechanisms that define the identity and position of cells in vertebrate embryos and to utilize this knowledge for the advancement of human medicine. This requires integration of model organism genetics with the discovery of novel disease-causing mutations in human genomes, and the Yost laboratory is recognized as a leader in understanding vertebrate left-right development and its contributions to complex congenital heart defects, which affect approximately thirty-five thousand births per year in the US.
Speaker: Dr. Lori Sussel, University of Colorado
May 27, 2021
The pancreas is a flat elongated pear shaped organ positioned behind the stomach. It is part of the digestive system and endocrine system of vertebrates. The pancreas synthesizes pancreatic juices, which contain enzymes that aid in digestion, and it produces several hormones, including insulin which regulates blood sugar levels. But what controls pancreas development and function? To date, only a handful of regulatory have been thoroughly characterized and many of the molecular pathways that specify islet cell differentiation and function are poorly understood.
Speaker: Gabrielle Kardon, Ph.D., University of Utah
March 25, 2021
How does muscle develop, regenerate, maintain, age, and evolve? These are the questions that drive our research. We focus on muscle stem cells because they are the source of all muscle. We focus on the muscle connective tissue because it provides the niche for muscle stem cells and is critical for muscle form and function. We study how interactions between muscle stem cells and the connective tissue orchestrate development of limb muscles and the diaphragm, regulate muscle regeneration and aging, are the source of birth defects and fibrosis, and shape evolution of the musculoskeletal system.
Speaker: Ralph Marcucio, Ph.D., University of California, San Francisco
February 25, 2021
Sometimes the data that are generated by experiments are very far from what is anticipated. As part of a translational project using cartilage to heal large bone defects, we discovered that chondrocytes transform into osteoblasts. This outcome contradicts more than 100 years of dogma that apoptosis is the terminal fate of chondrocytes, and has led to a discovery of new mechanisms of bone regeneration.